it seems possible that the novel indole cannabinoid AM-694 is finding its way into smoking blends and also because it is being sold as an RC into people.
this is a potentially dangerous development.
this is why.
The metabolism of all indole cannabinoids involves loss of the indole N substituent, in the case of JWH 018 this is a pretty harmless alkyl chain. However in the case of AM-694 the N-substituent is a terminal fluoro alkyl, (omega fluoro pentyl) most terminal alkyl fluorides are exceptionally toxic as they metabolise to fluoroacetic acid.
http://en.wikipedia.org/wiki/Fluoroacetate
w fluoroalcohols are also highly toxic 4-fluorobutanol has an LD50 in mice of 0.9mg/kg which makes it as toxic as some war gases.
http://article.pubs.nrc-cnrc.gc.ca/p...startPage=1532
whilst it is highly unlikely that sufficient fluoroacetic acid will be created by the metabolism of AM-694 to kill the consumer but fluoroacetate is dangerous even in sub lethal doses as it interferes with the generation of energy by cells. Fluoroacetate is used to kill vermin. In fact it completely screws up the Krebs cycle. AM-694 would effectively deliver this dose of fluoroacetate to the brain which is the most energy sensitive organ in the body. Repeated sub lethal exposures to fluoroacetate in animals have been linked to increased mortality liver damage, brain damage and damage to the reproductive organs. Fluoroacetate is regarded as a cumulative poison.
Do not ingest this AM-694 compound,
Until proper toxicological studies are available, it should be used as a research ligand for in- vitro use only.
